Sea Buckthorn Research Finder
Every study behind our claims in one filterable table: the trials, the doses, the verdicts, and the null results we publish anyway.
| Study | Topic | Design | Dose and size | Verdict | Evidence | Read more |
|---|---|---|---|---|---|---|
| Sea buckthorn fruit extract for chronic idiopathic constipationNutrients, 2026. Spontaneous complete bowel movements rose from about 1.5 to 2.6 a week and Bristol stool score from 1.4 to 3.5, both p below 0.001, with placebo unchanged. Flatulence and SF-12 quality of life did not move. The sponsor EPO S.r.l. supplied the extract free of charge, it ran 28 days at one center, and it tested a concentrated fruit extract rather than the oil. | Gut | Human RCT | 500 mg/day fruit extract, 28 daysn: 90 | Positive | ●●●○ | Deep divePMID 41829976 |
| Compound sea-buckthorn oil vaginal suppository before colposcopy (TOPICAL, not oral)Scientific Reports, 2025. Open-label three-arm trial in postmenopausal women attending colposcopy. The suppository and a vaginal estrogen ointment both made the exam readable where no pretreatment did not, and the two did not differ significantly from each other. The trial set no non-inferiority margin, so it detected no difference rather than proving equivalence. Estrogen caused breast discomfort in 5.6% and dizziness or headache in 4% against none on the suppository, while local vaginal discomfort was slightly more common on the suppository. Topical route only, and it says nothing about swallowing capsules. | Women's health | Human RCT | Vaginal suppository, 2 weeks (topical, not swallowed)n: 368 of 377 | Positive | ●●●○ | Deep divePMID 40133564 |
| Oral sea buckthorn oil on skin, blood markers, ocular, and vaginal healthJournal of Functional Foods, 2024. Placebo-controlled: hydration +8%, collagen density +10%, texture +14%, pore count -15%; blood catalase +82.8%, TNF-alpha -23%. Industry-funded with a small sample, so pair it with Yang 2009. | Skin | Human RCT | 1 g/day oil (Omegia), 12 weeksn: 40 | Positive | ●●●○ | Deep diveDOI 10.1016/j.jff.2023.105973 |
| Sea buckthorn and metabolic-syndrome factors: systematic review and meta-analysisPhytotherapy Research, 2022. Significant reductions in triglycerides, total cholesterol, and LDL, with HDL raised, strongest in people with abnormal blood lipids. No significant effect on fasting glucose, blood pressure, or BMI. | Heart and cholesterol | Meta-analysis | Oils, berries, and extracts across 15 RCTsn: 15 trials pooled | Mixed | ●●●● | Deep divePMID 36043374 |
| Genotoxicity and teratogenicity of sea buckthorn berry oilDrug and Chemical Toxicology, 2020. No treatment-related maternal or embryo toxicity in pregnant rats and no genotoxicity in three assays. This is the only pregnancy data that exists, it is in rats, dosing stopped at gestation day 16, and it does not license a human dose or say anything about breastfeeding. | Safety | Animal and lab study | 1.17, 2.34 and 4.68 g/kg in pregnant rats, gestation days 7 to 16n: Rats and mice, no human subjects | Null | ●●○○ | Deep divePMID 30081653 |
| RetractedSeabuckthorn seed oil in hypertensive subjectsClinical Nutrition, 2017. Reported that blood pressure normalized in hypertensive subjects, and that cholesterol, oxy-LDL and triglycerides fell in hypercholesterolemic subjects. The paper has been withdrawn, so none of those results stand.RETRACTED 2026, not usable as evidence. Clinical Nutrition withdrew this paper at the request of its Editor-in-Chief and Ethics Editor over image duplication across figures that the corresponding author could not explain. Retraction notice: Clin Nutr. 2026;59:106600. | Heart and cholesterol | Human RCT | 0.75 ml/day seed oil, 30 daysn: 106 | Retracted | ●○○○ | Deep divePMID 27522605 (retracted) |
| Abundance of active ingredients in sea-buckthorn oilLipids in Health and Disease, 2017. The reference behind our oil-composition ranges: palmitoleic acid (omega-7) roughly 15 to 54 percent of berry-oil fatty acids, plus carotenoids, tocopherols, and phytosterols. | Composition | Compositional analysis | Not an interventionn: Reference review | Context | ●○○○ | Deep diveDOI 10.1186/s12944-017-0469-7 |
| Phytochemical composition of sea buckthorn by cultivarJ Agricultural and Food Chemistry, 2015. Cultivar-level vitamin C, flavonoid, and carotenoid ranges. One of the two primary sources for the 200 to 600 mg per 100 g fresh-berry band we publish everywhere. | Composition | Compositional analysis | Not an interventionn: Cultivars compared | Context | ●○○○ | Deep diveDOI 10.1021/acs.jafc.5b00564 |
| Sea buckthorn oil for vaginal atrophy in postmenopausal womenMaturitas, 2014. About three times greater improvement in vaginal epithelial integrity vs placebo, with pH and maturation index unchanged, meaning a non-estrogenic mechanism. A support option, not a hormone replacement. | Women's health | Human RCT | 3 g/day oil, 3 monthsn: 116 | Positive | ●●●○ | Deep divePMID 25104582 |
| Fatty acids in berry lipids of six sea buckthorn cultivarsChemistry Central Journal, 2012. Cultivar-level fatty-acid measurements showing how widely berry and seed oil profiles swing by subspecies, the lab basis for our berry-vs-seed oil distinction. | Composition | Compositional analysis | Not an interventionn: 6 cultivars | Context | ●○○○ | Deep diveDOI 10.1186/1752-153X-6-106 |
| Oral sea buckthorn oil attenuates tear-film osmolarity and dry-eye symptomsJournal of Nutrition, 2010. The seasonal rise in tear-film osmolarity was significantly smaller than placebo; maximum redness scored 6% vs 36%. The other 23 tracked symptoms showed no significant difference. | Eyes | Human RCT | 2 g/day oil (1 g twice daily), 3 monthsn: 100 | Positive | ●●●○ | Deep divePMID 20554904 |
| Oral and topical CO2-extracted sea buckthorn oil on skin ageingJ Appl Cosmetol, 2009 (not PubMed-indexed). Skin hydration +33.6% at one month and +48.6% at three; elasticity +25.8%. Caveats: the oral arm was compared against topical, not placebo, and the oil was a branded, industry-linked product. | Skin | Small human trial | 2 g/day oral oil, 3 months, vs topical armn: 60 | Positive | ●●○○ | Deep diveHosted PDF |
| Sea buckthorn berries on infections and inflammationEuropean Journal of Clinical Nutrition, 2008. No effect on common-cold or digestive-infection rates in 254 healthy volunteers. C-reactive protein did decrease, a mild anti-inflammatory signal. The honesty anchor for immunity claims. | Immunity | Human RCT | 28 g/day whole berries, 3 monthsn: 254 | Null | ●●●○ | Deep divePMID 17593932 |
| Vitamin C in sea buckthorn berries and products: processing and storage lossesJournal of Food Science, 2008. About 400 mg per 100 g in berries; juice production lost only 5 to 11 percent, concentration about half, and cold storage roughly 11 to 12 percent per week. The numbers behind our processing-tax table. | Composition | Compositional analysis | Not an interventionn: Products tested | Context | ●○○○ | Deep divePMID 19021790 |
| Sea buckthorn berry oil inhibits platelet aggregationJ Nutr Biochem, 2000. Clear decrease in ADP-induced platelet aggregation vs coconut-oil control in 12 healthy men. A small signal, not proof, and the basis for our anticoagulant and pre-surgery cautions. | Safety | Small human trial | 5 g/day berry oil, 4 weeks, crossovern: 12 | Positive | ●●○○ | Deep divePMID 11120446 |
15 studies listed. Null results sit alongside positive ones, a Context verdict marks composition papers that inform our ranges without testing outcomes in people, and a Retracted verdict marks a paper that has been withdrawn and cannot support any claim. Level dots follow the same four-tier scale as the evidence grades on our pages.
How we grade and why we publish nulls: how to read a studyand the research hub.